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Published April 27, 2007 | Supplemental Material
Journal Article Open

A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila

Abstract

One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements in Drosophila that drive population replacement and are resistant to recombination-mediated dissociation of drive and disease refractoriness functions. These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene.

Additional Information

© 2007 American Association for the Advancement of Science. 8 December 2006; Accepted 20 March 2007; Published online 29 March 2007. This work did not receive specific funding. It was supported by NIH grants GM057422 and GM70956 to B.A.H. and NS042580 and NS048396 to M.G. C.-H.C. was supported by the Moore Foundation Center for Biological Circuit Design. We thank two reviewers for useful comments and improvements on the manuscript. GenBank accession numbers for Medea^(myd88) and Medea^(myd88-int) are EF447106 and EF447105, respectively.

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