Published March 24, 2000
| Accepted Version
Journal Article
Open
Comparative Genomics of the Eukaryotes
- Creators
- Rubin, Gerald M.
- Hay, Bruce A.
Abstract
A comparative analysis of the genomes ofDrosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae—and the proteins they are predicted to encode—was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
Additional Information
© 2000 American Association for the Advancement of Science. The many participants from academic institutions are grateful for their various sources of support. Participants from the Berkeley Drosophila Genome Project are supported by NIH grant P50HG00750 (G.M.R.) and grant P4IHG00739 (W.M.G.).Attached Files
Accepted Version - nihms142596.pdf
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nihms142596.pdf
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Additional details
- PMCID
- PMC2754258
- Eprint ID
- 51734
- Resolver ID
- CaltechAUTHORS:20141114-074753633
- P50HG00750
- NIH
- P4IHG00739
- NIH
- Created
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2014-11-14Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field