Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

Creators: Melov, Simon; Ravenscroft, Joanne; Malik, Sarwatt; Gill, Matt S.; Walker, David W.; Clayton, Peter E.; Wallace, Douglas C.; Malfroy, Bernard; Doctrow, Susan R.; Lithgow, Gordon J.

Abstract

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

Additional Information

© 2000 American Association for the Advancement of Science. 27 March 2000; accepted 11 July 2000. We thank the Lithgow lab and A. Seyed Jazayeri-Dezfuly for critical and helpful discussions. M.S.G. is a Medical Research Council (MRC)-supported Training Fellow. D.W.W. is also supported by the MRC, and S. Malik was supported by Research into Aging. D.C.W. and S. Melov were supported in part by NIH grants AG-13154 and NS21328, awarded to D.C.W. All strains were obtained from the Caenorhabditis Genetics Center.

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Resource type: Journal Article
Publisher: American Association for the Advancement of Science
Published in: Science, 289(5484), 1567-1569, ISSN: 0036-8075.