Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published June 3, 2015 | Accepted Version + Supplemental Material
Journal Article Open

Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters

Abstract

An improved method for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters is described. The asymmetric alkylation demonstrated was achieved up to 70% ee utilizing a copper(II) bis(phosphine) complex.

Additional Information

© 2014 Elsevier B.V. Received 30 September 2014; Received in revised form 24 October 2014; accepted 27 October 2014. The authors wish to thank NIH-NIGMS (R01GM080269-01), Amgen, the Gordon and Betty Moore Foundation, and Caltech for financial support. S.-J.H thanks Fulbright Commission (Foreign Student Program, No. 15111120) and the Ilju Foundation of Education & Culture (Pre-doctoral Research Fellowship) for financial support. Catalyst center (Caltech) is acknowledged for assistance with reaction screenings. Drs. Florian Vogt, Sandy Ma, Xiaoquing Han, and Shyam Krishnan are acknowledged for preliminary research.

Attached Files

Accepted Version - nihms-638763.pdf

Supplemental Material - mmc1.pdf

Files

mmc1.pdf
Files (1.2 MB)
Name Size Download all
md5:b74778b102606a38cfa06d61c154f286
371.2 kB Preview Download
md5:e0ed70f6bf4f9cc23217100d085fbf13
829.3 kB Preview Download

Additional details

Created:
August 22, 2023
Modified:
October 18, 2023