Published September 1, 2014
| public
Journal Article
MicroRNA-125b Represses IRF4 to Induce Acute Myeloid Leukemia
- Creators
- Chaudhuri, A.
- So, A. Y.
- Sookram, R.
-
Baltimore, D.
Abstract
MicroRNA-125b (miR-125b) is upregulated in a variety of neoplastic blood disorders. We previously showed that miR-125b expression is enriched in hematopoietic stem and progenitor cells (HSPCs), and that upregulation of miR-125b in the mouse hematopoietic system causes an aggressive acute myeloid leukemia. Here we elucidate the molecular mechanism by which miR-125b causes acute myeloid leukemia.
Additional Information
© 2014 Published by Elsevier Inc. Author Disclosure: A. Chaudhuri: None. A.Y. So: None. R. Sookram: None. D. Baltimore: K. Advisory Board; Regulus Therapeutics.Additional details
- Eprint ID
- 50774
- DOI
- 10.1016/j.ijrobp.2014.05.2230
- Resolver ID
- CaltechAUTHORS:20141024-094315621
- Created
-
2014-10-24Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field