"Ultra-Clean" Isotope Dilution/Mass Spectrometric Analyses for Lead in Human Blood Plasma Indicate That Most Reported Values Are Artificially High
- Creators
- Everson, Joel
- Patterson, C. C.
Abstract
We measured lead concentrations in venous blood plasma from two subjects, one having a typical exposure and the other a high exposure to lead. Our preliminary data, obtained by isotope dilution/mass spectrometric techniques in an ultra-clean laboratory, show lead concentrations of 0.02 µg/L and 2 µg/L, respectively, in their blood plasma, and 110 µg/L and 800 µg/L, respectively, in samples of whole blood. These results indicate that plasma lead concentrations previously reported have been overestimated by a large factor, and that further improvements in analytical procedures are needed in most laboratories before data on lead concentrations in blood plasma can be properly interpreted. Our preliminary data indicate a positive correlation between lead intake and lead concentrations in blood plasma.
Additional Information
© 1980 The American Association for Clinical Chemistry. Received May 9, 1980; accepted June 30, 1980. We gratefully acknowledge support by the Treadway Trust Fund. This reeearch was supported in part by NSF grant DEB73-01306 A01. Dr. C. C. Culver provided invaluable assistance in locating an occupationally exposed subject with high blood-lead concentrations. D. Settle, M. Burnett, and D. Northfelt aided in developing procedures for the collection and analysis of samples. Nurse R. Canby carried out the venipunctures required for sample collection.Additional details
- Eprint ID
- 49700
- Resolver ID
- CaltechAUTHORS:20140915-104230228
- Treadway Trust Fund
- DEB73-01306 A01
- NSF
- Created
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2014-09-15Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field