Published August 19, 2014
| Published
Journal Article
Open
Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease
Abstract
We agree with Brunet and Doolittle (1) on the utility of distinguishing the evolutionarily selected effects (SE) of some genomic elements from the causal roles (CR) of other elements that lack signatures of selection (1⇓⇓–4). DNA sequences identified by biochemical approaches include both SE and CR elements, and genetic variation in both has been implicated in human traits and disease susceptibility. We thus view the Encyclopedia of DNA Elements (ENCODE) catalog and similar data resources as important foundations for understanding the DNA elements and molecular mechanisms underlying human biology and disease.
Additional Information
© 2014 2014 National Academy of Sciences. Published online before print August 8, 2014. Author contributions: M.K., B.W., M.P.S., B.E.B., and R.C.H. designed research; M.K., B.W., M.P.S., B.E.B., A.K., G.K.M., L.D.W., and R.C.H. performed research; M.K., B.W., M.P.S., B.E.B., A.K., G.K.M., L.D.W., and R.C.H. analyzed data; and M.K., B.W., M.P.S., B.E.B., A.K., G.K.M., L.D.W., E.B., G.E.C., J.D., I.D., L.L.E., P.J.F., E.A.F., M.G., M.C.G., D.M.G., T.R.G., E.D.G., R.G., T.H., J.K., J.D.L., R.M.M., M.J.P., B.R., J.S., Z.W., K.P.W., and R.C.H. wrote the paper. The authors declare no conflict of interest.Attached Files
Published - PNAS-2014-Kellis-E3366.pdf
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Additional details
- PMCID
- PMC4143047
- Eprint ID
- 49627
- Resolver ID
- CaltechAUTHORS:20140911-151755000
- Created
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2014-09-11Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field