Published June 2014
| Accepted Version
Journal Article
Open
Prokaryotic Argonautes defend genomes against invasive DNA
Abstract
Argonaute proteins are central players in small RNAmediated silencing mechanisms such as RNA interference (RNAi), microRNA repression and piRNA-mediated transposon silencing. In eukaryotes, Argonautes bind small RNAs that guide them to RNA targets in order to regulate gene expression and repress invasive genomic elements. Although Argonaute proteins are conserved in all life forms from bacteria to eukaryotes, until now studies have focused on the biological functions of eukaryotic Argonautes. Here we highlight two recent studies that discover the functions of prokaryotic Argonautes in defence against exogenous DNA.
Additional Information
© 2014 Elsevier Ltd. Available online 13 May 2014. We thank members of the Aravin lab for discussion and Alexandre Webster for critical reading of the manuscript. Research in Aravin lab is supported by grants from the National Institutes of Health (HD057233, GM097363, and OD007371A) and by the Searle Scholar and the Packard Fellowship Awards.Attached Files
Accepted Version - nihms591653.pdf
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Additional details
- PMCID
- PMC4041519
- Eprint ID
- 45862
- Resolver ID
- CaltechAUTHORS:20140521-090032542
- HD057233
- NIH
- GM097363
- NIH
- OD007371A
- NIH
- Searle Scholar Award
- Packard Fellowship Award
- Created
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2014-05-27Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field