Line active molecules promote inhomogeneous structures in membranes: Theory, simulations and experiments
Abstract
We review recent theoretical efforts that predict how line-active molecules can promote lateral heterogeneities (or domains) in model membranes. This fundamental understanding may be relevant to membrane composition in living cells, where it is thought that small domains, called lipid rafts, are necessary for the cells to be functional. The theoretical work reviewed here ranges in scale from coarse grained continuum models to nearly atomistic models. The effect of line active molecules on domain sizes and shapes in the phase separated regime or on fluctuation length scales and lifetimes in the single phase, mixed regime, of the membrane is discussed. Recent experimental studies on model membranes that include line active molecules are also presented together with some comparisons with the theoretical predictions.
Additional Information
© 2014 Elsevier B.V. Available online xxxx. We are grateful for discussions with David Andelman, Shigeyuki Komura, Gerald Feigenson, Michael Schick, Martin Grant, Jonathan Amazon, David Ackerman, Siewert-Jan Marrink, Benjamin Machta, Sarah Veatch, Sarah Keller, James Sethna, Uri Raviv and Lia Addadi. The Israel Science Foundation, the Schmidt Minerva Center and the historic generosity of the Perlman Family Foundation are gratefully acknowledged for funding this research. Benoit Palmieri is grateful to the Azrieli Foundation for the award of an Azrieli Fellowship.Additional details
- Eprint ID
- 44587
- Resolver ID
- CaltechAUTHORS:20140401-144404521
- Israel Science Foundation
- Schmidt Minerva Center
- Perlman Family Foundation
- Azrieli Foundation Azrieli Fellowship award
- Created
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2014-04-01Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field