The Projective Field of Retinal Bipolar Cells and Its Modulation by Visual Context
- Creators
- Asari, Hiroki
- Meister, Markus
Abstract
The receptive field of a sensory neuron spells out all the receptor inputs it receives. To understand a neuron's role in the circuit, one also needs to know its projective field, namely the outputs it sends to all downstream cells. Here we present the projective fields of the primary excitatory neurons in a sensory circuit. We stimulated single bipolar cells of the salamander retina and recorded simultaneously from a population of ganglion cells. Individual bipolar cell signals diverge through polysynaptic pathways into ganglion cells of many different types and over surprisingly large distance. However, the strength and polarity of the projection depend on the cell types involved. Furthermore, visual stimulation strongly modulates the bipolar cell projective field, in opposite direction for different cell types. In this way, the context from distant parts of the visual field can control the routing of signals in the inner retina.
Additional Information
© 2014 Elsevier Inc. Accepted: November 21, 2013. Published: February 5, 2014. We gratefully acknowledge Ed Soucy for assistance with experiments. This work was supported by a Postdoctoral Fellowship for Research Abroad from the Japan Society for the Promotion of Science (H.A.) and grants from the U.S. National Institutes of Health (M.M.). Author Contributions: H.A. and M.M. designed the study and wrote the manuscript. H.A. performed experiments and analysis.Attached Files
Supplemental Material - mmc1.pdf
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Additional details
- Eprint ID
- 44410
- Resolver ID
- CaltechAUTHORS:20140320-111914365
- Japan Society for the Promotion of Science (JSPS)
- NIH
- Created
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2014-03-20Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field