Frequency-Specific Alternations in the Amplitude of Low-Frequency Fluctuations in Schizophrenia
Abstract
Schizophrenia has been associated with abnormal task-related brain activation in sensory and motor regions as well as social cognition network. Recently, two studies investigated temporal correlation between resting-state functional magnetic resonance imaging (R-fMRI) low-frequency oscillations (LFOs) in schizophrenia but reported mixed results. This may be due to the different frequency bands used in these studies. Here we utilized R-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) in three different frequency bands (slow-5: 0.01–0.027 Hz; slow-4: 0.027–0.08 Hz; and typical band: 0.01–0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. We showed that there were significant differences in ALFF/fALFF between the two bands (slow-5 and slow-4) in regions including basal ganglia, midbrain, and ventromedial prefrontal cortex. Importantly, we also identified significant interaction between frequency bands and groups in inferior occipital gyrus, precunus, and thalamus. The results suggest that the abnormalities of LFOs in schizophrenia is dependent on the frequency band and suggest that future studies should take the different frequency bands into account when measure intrinsic brain activity.
Additional Information
© 2012 Wiley Periodicals, Inc. Received for publication 13 February 2012; Revised 30 July 2012; Accepted 21 August 2012. Published online 5 November 2012 in Wiley Online Library. Rongjun Yu and Yi-Ling Chien contributed equally to this work. Contract grant sponsor: National Science Council, Taiwan; Contract grant numbers: NSC100-3112-B-002-016, NSC100-2321-B-002-015; Contract grant sponsor: National Health Research Institute, Taiwan; Contract grant number: NHRI-EX101-10145NI; Contract grant sponsor: Department of Medical Imaging and Advanced Biomedical MRI Laboratory; National Taiwan University Hospital, Taipei, Taiwan. The authors thank all of the participants for their involvement in this study.Attached Files
Supplemental Material - hbm22203-sup-0001-SuppFig1.tif
Supplemental Material - hbm22203-sup-0002-SuppFig2.tif
Supplemental Material - hbm22203-sup-0003-SuppFig3.tif
Supplemental Material - hbm22203-sup-0004-SuppTab1.doc
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Additional details
- Eprint ID
- 43627
- Resolver ID
- CaltechAUTHORS:20140203-140142874
- NSC100-3112-B-002-016
- National Science Council (Taipei)
- NSC100-2321-B- 002-015
- National Science Council (Taipei)
- NHRI-EX101-10145NI
- National Science Council (Taipei)
- National Taiwan University Hospital,
- Created
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2014-02-03Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field