Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published January 2014 | public
Journal Article

A MicroRNA-mediated feedback loop controls vascular inflammatory signaling

Abstract

Activation of inflammatory signaling pathways in the endothelium contributes to vascular diseases, including sepsis and atherosclerosis. We find that a microRNA family (miR-146a and miR-J46b) is induced in endothelial cells upon exposure to pro-inflammatory cytokinc. Although transcription of the miR-146alb loci is rapidly induced, induction of mature miR-146a/b is delayed and sustained compared to the expression of leukocyte adhesion molecules, and in fact coincides with the down-regulation of inflammatory gene expression.

Additional Information

© 2013 Springer Science+Business Media Dordrecht.

Additional details

Created:
August 19, 2023
Modified:
October 25, 2023