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Published January 27, 2014 | Published
Journal Article Open

To be or not to be a piRNA: genomic origin and processing of piRNAs

Abstract

Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate.

Additional Information

© 2014 Le Thomas et al.; licensee BioMed Central Ltd. The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Published: 27 January 2014. We thank Evelyn Stuwe for help with figure preparation and members of the Aravin laboratory for discussion. This work was supported by grants from the National Institutes of Health (R00 HD057233, R01 GM097363 and DP2 OD007371A), the Searle Scholar, the Packard Fellowship Awards and the Ellison Medical Foundation New Scholar Aging Award.

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