Multilevel Modulation of a Sensory Motor Circuit during C. elegans Sleep and Arousal
- Creators
- Cho, Julie Y.
-
Sternberg, Paul W.
Abstract
Sleep is characterized by behavioral quiescence, homeostasis, increased arousal threshold, and rapid reversibility. Understanding how these properties are encoded by a neuronal circuit has been difficult, and no single molecular or neuronal pathway has been shown to be responsible for the regulation of sleep. Taking advantage of the well-mapped neuronal connections of Caenorhabditis elegans and the sleep-like states in this animal, we demonstrate the changed properties of both sensory neurons and downstream interneurons that mediate sleep and arousal. The ASH sensory neuron displays reduced sensitivity to stimuli in the sleep-like state, and the activity of the corresponding interneurons in ASH's motor circuit becomes asynchronous. Restoration of interneuron synchrony is sufficient for arousal. The multilevel circuit depression revealed provides an elegant strategy to promote a robust decrease in arousal while allowing for rapid reversibility of the sleep state.
Additional Information
© 2014 Elsevier Inc. Received: May 25, 2013; Revised: September 26, 2013; Accepted: November 15, 2013; Published: January 16, 2014. We thank William Schafer (University of Cambridge), Alexander Gottschalk (Johann Wolfgang Goethe University), Elissa Hallem (University of California, Los Angeles), and the Caenorhabditis Genetics Center (University of Minnesota) for worm strains and Karl Deisseroth (Stanford University) for channelrhodopsin constructs. We also thank David Anderson, David Prober, Alon Zaslaver, Trevor Fowler, and Lauren Lebon for their input and Meenakshi Doma, Yen-ping Hsueh, Mihoko Kato, Hillel Schwartz, and members of our lab for editorial comments. J.Y.C. was supported by National Institutes of Health USPHS training grant GM07616. This work was supported by the Howard Hughes Medical Institute, with which P.W.S. is an investigator, and by NIH grant DA018341 to P.W.S.Attached Files
Accepted Version - nihms552435.pdf
Files
| Name | Size | Download all |
|---|---|---|
|
md5:5bfe402add8c7db9eb945f18549389ff
|
2.6 MB | Preview Download |
Additional details
- PMCID
- PMC3962823
- Eprint ID
- 43481
- Resolver ID
- CaltechAUTHORS:20140123-085452909
- GM07616
- NIH USPHS Training Grant
- Howard Hughes Medical Institute (HHMI)
- DA018341
- NIH
- Created
-
2014-01-23Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field