Kawasaki disease and ENSO-driven wind circulation
Abstract
Kawasaki disease (KD) is the most common cause of acquired heart disease in children worldwide. Recently, a climatological study suggested that KD may be triggered by a windborne agent traveling across the north Pacific through the westerly wind flow prevailing at midlatitudes. Here we use KD records to describe the association between enhanced disease activity on opposite sides of the basin and different phases of the El Niño-Southern Oscillation (ENSO) phenomenon, via the linkage to these tropospheric winds. Results show that years with higher-than-normal KD cases in Japan preferentially occur during either El Niño Modoki or La Niña conditions, while in San Diego during the mature phase of El Niño or La Niña events. Given that ENSO offers a degree of predictability at lead times of 6 months, these modulations suggest that seasonal predictions of KD could be used to alert clinicians to periods of increased disease activity.
Additional Information
© 2013 American Geophysical Union. Received 29 January 2013; revised 18 March 2013; accepted 19 March 2013; published 29 May 2013. This study was funded by project 081910 "Kawasaki disease: Disentangling the role of Climate in the outbreaks" from "La Marató de TV3 (2008): malalties cardiovasculars" through a grant awarded to Xavier Rodó. Joan Ballester was supported in part by a fellowship from the Catalan Ministry of Innovation and Science. This work was also supported in part by a grant from the National Institutes of Health, National Heart, Lung, Blood Institute (HL69413) awarded to Jane C. Burns, and by the NOAA Regional Integrated Sciences and Assessments through the California Applications program awarded to Dan Cayan.Attached Files
Published - grl50388.pdf
Supplemental Material - grl50388-sup-0001-Supplementary_Figure_1.jpg
Supplemental Material - grl50388-sup-0002-Supplementary_Figure_2.jpg
Supplemental Material - grl50388-sup-0003-Supplementary_Figure_3.jpg
Supplemental Material - grl50388-sup-0004-Supplementary_Figure_4.jpg
Supplemental Material - grl50388-sup-0005-Supplementary_Figure_5.jpg
Supplemental Material - grl50388-sup-0006-Supplementary_Material.doc
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Additional details
- Eprint ID
- 43425
- Resolver ID
- CaltechAUTHORS:20140117-100742077
- 081910
- La Marato de TV3
- Catalan Ministry of Innovation and Science
- HL69413
- NIH National Heart, Lung, Blood Institute
- NOAA Regional Integrated Sciences and Assessments
- Created
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2014-01-17Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field