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Published October 23, 2013 | Published
Journal Article Open

Local Generation and Propagation of Ripples along the Septotemporal Axis of the Hippocampus

Abstract

A topographical relationship exists between the septotemporal segments of the hippocampus and their entorhinal–neocortical targets, but the physiological organization of activity along the septotemporal axis is poorly understood. We recorded sharp-wave ripple patterns in rats during sleep from the entire septotemporal axis of the CA1 pyramidal layer. Qualitatively similar ripples emerged at all levels. From the local seed, ripples traveled septally or temporally at a speed of ∼0.35 m/s, and the spatial spread depended on ripple magnitude. Ripples propagated smoothly across the septal and intermediate segments of the hippocampus, but ripples in the temporal segment often remained isolated. These findings show that ripples can combine information from the septal and intermediate hippocampus and transfer integrated signals downstream. In contrast, ripples that emerged in the temporal pole broadcast largely independent information to their cortical and subcortical targets.

Additional Information

© 2013 the authors. Received May 14, 2013; revised Sept. 12, 2013; accepted Sept. 17, 2013. Author contributions: J.P. and G.B. designed research; J.P. and A.B. performed research; J.P., E.W.S., A.B., and S.F. contributed unpublished reagents/analytic tools; J.P., E.W.S., and G.B. analyzed data; J.P. and G.B. wrote the paper. This work was supported by National Institute of Health Grants NS34994, MH54671, and NS074015, National Science Foundation Grant SBE 0542013, the Human Frontier Science Program, and the James S. McDonnell Foundation. We thank A. Amarasingham for comments on this manuscript.

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Created:
August 19, 2023
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October 25, 2023