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Published August 3, 2004 | Accepted Version
Journal Article Open

Formation of arrayed droplets of soft lithography and two-phase fluid flow, and application in protein crystallization

Abstract

This paper presents an overview of our recent work on the use of soft lithography and two-phase fluid flow to form arrays of droplets. The crucial issues in the formation of stable arrays of droplets and alternating droplets of two sets of aqueous solutions include the geometry of the microchannels, the capillary number, and the water fraction of the system. Glass capillaries could be coupled to the PDMS microchannels and droplets could be transferred into glass capillaries for long-term storage. The arrays of droplets have been applied to screen the conditions for protein crystallization with microbatch and vapor diffusion techniques.

Additional Information

© 2004 WILEY-VCH. Issue published online: 25 AUG 2004. Article first published online: 25 AUG 2004. This work was supported in part by the NIH (R01 EB001903) and the Beckman Young Investigator Program, and was performed at the MRSEC microfluidic facility funded by the NSF.

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August 22, 2023
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