Reactions in droplets in microfluidic channels
Abstract
Fundamental and applied research in chemistry and biology benefits from opportunities provided by droplet-based microfluidic systems. These systems enable the miniaturization of reactions by compartmentalizing reactions in droplets of femoliter to microliter volumes. Compartmentalization in droplets provides rapid mixing of reagents, control of the timing of reactions on timescales from milliseconds to months, control of interfacial properties, and the ability to synthesize and transport solid reagents and products. Droplet-based microfluidics can help to enhance and accelerate chemical and biochemical screening, protein crystallization, enzymatic kinetics, and assays. Moreover, the control provided by droplets in microfluidic devices can lead to new scientific methods and insights.
Additional Information
© 2006 WILEY-VCH. Received: April 19, 2006. Revised: July 4, 2006. The research in our laboratory has been supported by the NIH (National Institute for Biomedical Imaging and Bioengineering R01 EB001903 and the National Institute of General Medical Sciences R01 GM075827), the Beckman Young Investigator Program, and by the DuPont Young Professor Award. We thank Joshua D. Tice for the images in Figure 9 and all members of our research group for their work described herein. We thank our colleagues in the field of droplet-based microfluidics for providing figures and for valuable suggestions.Attached Files
Accepted Version - nihms14617.pdf
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Additional details
- PMCID
- PMC1766322
- Eprint ID
- 40871
- Resolver ID
- CaltechAUTHORS:20130821-160732141
- R01 EB001903
- NIH
- R01 GM075827
- NIH
- Arnold and Mabel Beckman Foundation
- E. I. DuPont de Nemours and Company, Inc.
- Created
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2013-08-27Created from EPrint's datestamp field
- Updated
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2023-06-02Created from EPrint's last_modified field