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Published March 12, 2004 | public
Journal Article

Minimal Functional Model of Hemostasis in a Biomimetic Microfluidic System

Abstract

The proof of the model is in the function: A minimal model of hemostasis (a complex biochemical network responsible for blood coagulation) may be implemented with only three chemical reactions, which creates a biomimetic functional microfluidic system that is capable of repairing itself (as modeled in the figure). This simple system shows threshold response and sensitivity to flow similar to that observed in hemostasis.

Additional Information

Copyright © 2004 WILEY-VCH. Issue published online: 9 MAR 2004. Article first published online: 24 FEB 2004. Manuscript Received: 28 NOV 2003. This work was supported by NSF CAREER Award, Office of Naval Research Young Investigator Award (N00014-03-10482), Searle Scholars Program, and by Dreyfus New Faculty Award. We thank Professors G. M. Whitesides, C. Chen, C. Hall, T. Van Ha, V. Turitto, and M. LaBarbera for invaluable suggestions.

Additional details

Created:
August 22, 2023
Modified:
October 24, 2023