Published January 2010
| Published
Journal Article
Open
Endogenous Phenazine Antibiotics Promote Anaerobic Survival of Pseudomonas aeruginosa via Extracellular Electron Transfer
- Creators
- Wang, Yun
- Kern, Suzanne E.
- Newman, Dianne K.
Abstract
Antibiotics are increasingly recognized as having other, important physiological functions for the cells that produce them. An example of this is the effect that phenazines have on signaling and community development for Pseudomonas aeruginosa (L. E. Dietrich, T. K. Teal, A. Price-Whelan, and D. K. Newman, Science 321:1203-1206, 2008). Here we show that phenazine-facilitated electron transfer to poised-potential electrodes promotes anaerobic survival but not growth of Pseudomonas aeruginosa PA14 under conditions of oxidant limitation. Other electron shuttles that are reduced but not made by PA14 do not facilitate survival, suggesting that the survival effect is specific to endogenous phenazines.
Additional Information
© 2010 American Society for Microbiology. Received 2 September 2009; Accepted 24 October 2009. Published ahead of print on 30 October 2009. We thank Jordan Katz for his help with making the Pt mesh counter electrodes and Alexa Price-Whelan and other Newman lab members for discussions. This work was supported by grants to D.K.N. from the Packard Foundation and Howard Hughes Medical Institute and an NSF graduate research fellowship to S.E.K. D.K.N. is an Investigator with the Howard Hughes Medical Institute.Attached Files
Published - J._Bacteriol.-2010-Wang-365-9.pdf
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Additional details
- PMCID
- PMC2798253
- Eprint ID
- 37784
- Resolver ID
- CaltechAUTHORS:20130405-104044575
- Packard Foundation
- Howard Hughes Medical Institute (HHMI)
- NSF graduate research fellowship
- Created
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2013-04-08Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field
- Caltech groups
- Division of Geological and Planetary Sciences