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Published December 2012 | public
Journal Article

Computational multiscale modeling of embryo development

Abstract

Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell–cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modeling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modeling areas.

Additional Information

© 2012 Elsevier Ltd. Available online 6th September 2012. This work was supported (CP and PK) by the Swedish Foundation for Strategic Research (Senior Individual Grant A3 06:215). VC would like to acknowledge support from Prof. Elliot Meyerowitz.

Additional details

Created:
August 19, 2023
Modified:
October 23, 2023