Published February 2013
| Supplemental Material + Accepted Version
Journal Article
Open
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome
- Creators
- Pieper, Ursula
- Schlessinger, Avner
- Kloppmann, Edda
- Chang, Geoffrey A.
- Chou, James J.
- Dumont, Mark E.
- Fox, Brian G.
- Fromme, Petra
- Hendrickson, Wayne A.
- Malkowski, Michael G.
-
Rees, Douglas C.
- Stokes, David L.
- Stowell, Michael H. B.
- Wiener, Michael C.
- Rost, Burkhard
- Stroud, Robert M.
- Stevens, Raymond C.
- Sali, Andrej
Abstract
Given the recent successes in determining membrane-protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane-domain sequences that cluster into 1,201 families sharing more than 25% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%, providing structure and function information not otherwise available.
Additional Information
© 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. Received 16 August 2012; accepted 9 January 2013; published online 5 February 2013. We thank I. Wilson, H. Berman, J. Chin and P. Preusch for critical comments on the manuscript. Research was supported by the US National Institutes of Health PSI:Biology grants U54 GM094662 (A.S., U.P.), U54 GM094618 (R.C.S.), U54 GM094625 (R.M.S., A.S., U.P.), U54 GM094584 (B.G.F.), U54 GM094599 (P.F.), U54 GM094611 (M.C.W., M.E.D., M.G.M.), U54 GM094610 (G.A.C., D.C.R., M.H.B.S.), U54 GM094608 (J.J.C.), U54 GM095315 (W.A.H., B.R., E.K.) and U54 GM094598 (D.L.S.).Attached Files
Accepted Version - nihms460509.pdf
Supplemental Material - nsmb.2508-S1.pdf
Files
nihms460509.pdf
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Additional details
- PMCID
- PMC3645303
- Eprint ID
- 37376
- DOI
- 10.1038/nsmb.2508
- Resolver ID
- CaltechAUTHORS:20130307-133554833
- U54 GM094662
- NIH
- U54 GM094618
- NIH
- U54 GM094625
- NIH
- U54 GM094584
- NIH
- U54 GM094599
- NIH
- U54 GM094611
- NIH
- U54 GM094610
- NIH
- U54 GM094608
- NIH
- U54 GM095315
- NIH
- U54 GM094598
- NIH
- Created
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2013-03-08Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field