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Published January 2013 | Supplemental Material
Journal Article Open

Norepinephrine in the brain is associated with aversion to financial loss

Abstract

Understanding the molecular mechanism of extreme or impaired decision-making observed in neuropsychiatric disorders, such as pathological gambling and attention-deficit hyperactivity disorder (ADHD), could contribute to better assessment and the development of novel pharmacological therapies for those disorders. Typically, most people show a disproportionate distaste for possible losses compared with equal-sized gains. This human in vivo molecular imaging study has demonstrated that individuals with lower thalamic norepinephrine transporters (NET) showed more exaggerated aversion to financial loss.

Additional Information

© 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. Published online 21 February 2012. A part of this study is the result of 'Integrated research on neuropsychiatric disorders' carried out under the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT). This work was supported by Grants-in-aid for Scientific Research (23120009, 23680045), Takeda Science Foundation and Casio Science Foundation.

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