Published August 1, 1975
| Published
Journal Article
Open
Molecular mechanism for oscillation in flagella and muscle
- Creators
- Brokaw, Charles J.
Abstract
Two-state models for muscle cross-bridges, of the type originally detailed by Andrew Huxley, were examined. Rate functions for cross-bridge attachment and detachment can be chosen which yield a steady-state force-velocity relationship appropriate for the spontaneous generation of oscillatory contractions. Computer simulations have been used to demonstrate oscillation of such cross-bridge systems, and to demonstrate that distribution of this type of local shear oscillation along the length of a flagellum is sufficient for the generation of propagated bending waves.
Additional Information
© 1975 National Academy of Sciences. Communicated by Ray D. Owen, June 5, 1975. I am indebted to Dr. T. L. Hill and to Dr. I. R. Gibbons for acquainting me with their work in advance of publication and for helpful comments on this manuscript, and to Dr. T. K. Caughey for a helpful discussion of nonlinear oscillations. This work has been supported by NIH grants which have made possible the computer simulations (GM 21931) and the experimental work (GM 18711) which has stimulated the development of theoretical models.Attached Files
Published - BROpnas75.pdf
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Additional details
- Eprint ID
- 32704
- Resolver ID
- CaltechAUTHORS:20120725-095601278
- GM 21931
- NIH
- GM 18711
- NIH
- Created
-
2012-07-25Created from EPrint's datestamp field
- Updated
-
2019-10-03Created from EPrint's last_modified field