The Brain Activity Map Project and the Challenge of Functional Connectomics

Creators: Alivisatos, A. Paul; Chun, Miyoung; Church, George M.; Greenspan, Ralph J.; Roukes, Michael L.; Yuste, Rafael

Abstract

The function of neural circuits is an emergent property that arises from the coordinated activity of large numbers of neurons. To capture this, we propose launching a large-scale, international public effort, the Brain Activity Map Project, aimed at reconstructing the full record of neural activity across complete neural circuits. This technological challenge could prove to be an invaluable step toward understanding fundamental and pathological brain processes.

Additional Information

© 2012 Elsevier Inc. Available online 20 June 2012. This collaboration arose from a workshop held at Chicheley Hall, the Kavli Royal Society International Centre, supported by The Kavli Foundation, the Gatsby Charitable Foundation, and the Allen Institute for Brain Science. We also thank A.S. Chiang, K. Deisseroth, S. Fraser, C. Koch, E. Marder, O. Painter, H. Park, D. Peterka, S. Seung, A. Siapas, A. Tolias, and X. Zhuang— participants at a smaller, subsequent Kavli Futures Symposium, where initial ideas were jointly refined. We acknowledge support from the DOE (A.P.A.), NHGRI (G.M.C.), NIH and the Mathers Foundation (R.J.G.), NIH and Fondation pour la Recherche et l'Enseignement Superieur, Paris (M.L.R.), and the Keck Foundation and NEI (R.Y.). A more extensive version of this paper and additional documents about the BAM can be found at http://hdl.handle.net/10022/AC:P:13501.

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