Abelson Virus Abrogation of Interleukin-3 Dependence in a Lymphoid Cell Line

Creators: Mathey-Prevot, Bernard; Nabel, Gary; Palacios, Ronald; Baltimore, David

Abstract

Among several tyrosine-protein kinases, only v-abl could abrogate interleukin 3 dependence of a lymphoblastoid cell line; v-src and v-fps proteins gave partial or no interleukin 3 independence, respectively. Lymphokine independence was achieved via a nonautocrine mechanism. Direct involvement of c-myc in this process was not evident.

Additional Information

© 1986 American Society for Microbiology. Received 17 April 1986; Accepted 3 July 1986. We thank Alan Korman (Whitehead Institute, Cambridge, Mass.) for his gift of pDOL plasmid. We are grateful to Bob Finkelstein for his critical reading of the manuscript and especially to Nancy Andrews for valuable suggestions on the manuscript and critical discussion of the experiments. This work was supported by grant CA38497 from the National Cancer Institute. B.M.-P. is a recipient of a fellowship from the Helen Hay Whitney Foundation; G.N. was supported by Howard Hughes Medical Institute, Boston, Mass.

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