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Published October 1987 | Published
Journal Article Open

A Lithium-sensitive Regulator of Sperm Flagellar Oscillation Is Activated by cAMP-dependent Phosphorylation

Abstract

Specific effects of both in vivo activation and in vitro activation by cAMP-dependent phosphorylation on bending wave parameters of demembranated, reactivated, tunicate (Ciona intestinalis) and sea urchin (Lytechinus pictus) sperm flagella can be reversed by exposure to protein phosphatase. The effects of protein phosphatase incubation can be imitated by inclusion of LiCl in the reactivation solutions. The primary effect of cAMP-dependent phosphorylation appears to be activation of a regulatory mechanism controlling flagellar oscillation, rather than activation of the active sliding mechanism. Lithium appears to act on the same regulatory mechanism.

Additional Information

© 1987 Rockefeller University Press. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Article under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode, or updates thereof. Received for publication 19 March 1987, and in revised form 15 June 1987. The contributions of Sandra Nagayama and Larry Jones to this work were substantial, and are acknowledged with thanks. This work has been supported by grant GM 18711 from the National Institutes of Health.

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August 19, 2023
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