Published April 2012
| Supplemental Material
Journal Article
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Utilizing Terminal Oxidants to Achieve P450-Catalyzed Oxidation of Methane
Abstract
Terminal oxidant-supported P450 reactions alleviate the need for substrate binding to initiate catalysis by chemically generating "compound I." This allows investigation of the innate substrate range of the enzyme active site. Using iodosylbenzene as the oxidant, CYP153A6, a medium-chain terminal alkane hydroxylase, exhibits methanol formation in the presence of methane demonstrating that P450-mediated methane hydroxylation is possible.
Additional Information
© 2012 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim. Received: October 25, 2011; Published online: April 4, 2012. This work was supported by the Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Science, U.S. Department of Energy grant DE-FG02-06ER15762. We thank Dr. Nathan Dalleska for assistance with gas chromatography and Dr. Jared Lewis for helpful discussion.Attached Files
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Additional details
- Eprint ID
- 31599
- DOI
- 10.1002/adsc.201100833
- Resolver ID
- CaltechAUTHORS:20120522-134624475
- DE-FG02-06ER15762
- Department of Energy (DOE)
- Created
-
2012-05-22Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field