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Published March 8, 2012 | Published
Journal Article Open

MicroRNAs in B cell development and malignancy

Abstract

MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and is also critical at the level of specific miRNAs. In this review, we discuss miRNAs that are involved in normal B cell development in the bone marrow and during B cell activation and terminal differentiation in the periphery. Next, we turn to miRNAs that are dysregulated during diseases of B cells, including malignant diseases and autoimmunity. Further study of miRNAs and their targets will lead to a better understanding of B cell development, and should also lead to the development of novel therapeutic strategies against B cell diseases.

Additional Information

© 2012 Fernando et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received: 16 February 2012 Accepted: 8 March 2012. Published: 8 March 2012. In this review we focused on those miRNAs that have some functional role in B cell development or lymphoma, thus we acknowledge that we may not have included many papers describing profiling studies on miRNAs. We would like to thank Jorge Contreras for his help and support in the completion of this article. TF is a recipient of Developmental Hematology Training Grant T32HL086345-05 from the National Institute of Health (NIH). NIRM is a recipient of the Eugene V. Cota-Robles Fellowship from UCLA and of the Graduate Research Fellowship Program from the National Science Foundation (NSF). DSR is a Kimmel Scholar of the Sidney Kimmel Foundation for Cancer Research and received a career development award from the NIH (5 K08-CA133251). Authors' contributions: TF and NIRM participated in its design and coordination and drafted the manuscript. DR conceived of the review, and participated in its design and coordination and drafted the manuscript. All authors read and approved the final manuscript.

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