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Published January 30, 2012 | Published
Book Section - Chapter Open

In vivo human retinal and choroidal vasculature visualization using differential phase contrast swept source optical coherence tomography at 1060 nm

Abstract

A differential phase contrast (DPC) method is validated for in vivo human retinal and choroidal vasculature visualization using high-speed swept-source optical coherence tomography (SS-OCT) at 1060 nm. The vasculature was identified as regions of motion by creating differential phase variance (DPV) tomograms: multiple B-scans were collected of individual slices through the retina and the variance of the phase differences was calculated. DPV captured the small vessels and the meshwork of capillaries associated with the inner retina in en face images over 4 mm^2 in a normal subject. En face DPV images were capable of capturing the microvasculature and regions of motion through the inner retina and choroid.

Additional Information

© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). Online Jan 30, 2012. This work was supported in part by research from the California Institute for Regenerative Medicine (CIRM). The authors thank Carl Zeiss Meditec for providing the patient interface part of their Stratus OCT system.

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