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Published June 1997 | public
Journal Article

Interaction of ion channels and receptors with PDZ domain proteins

Abstract

The complex anatomy of neurons demands a high degree of functional organization. Therefore, membrane receptors and ion channels are often localized to selected subcellular sites and coupled to specific signal transduction machineries. PDZ domains have come into focus as protein interaction modules that mediate the binding of a class of submembraneous proteins to membrane receptors and ion channels and thus subserve these organizational aspects. The structures of two PDZ domains have been resolved, which has led to a structural understanding of the specificity of interactions of various PDZ domains with their respective partners. The functional implications of PDZ domain interactions are now being addressed in vitro and in vivo.

Additional Information

© 1997 Current Biology Ltd. Available online 11 February 2002. The authors' work is supported by U.S. Public Health Service grant NS-28710 to MB Kennedy and by Deutsche Forschungsgemeinschaft grant SFB317/B9 to PH Seeburg.

Additional details

Created:
August 19, 2023
Modified:
October 17, 2023