The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
- Creators
- Cho, Kyung-Ok
- Hunt, Carol A.
-
Kennedy, Mary B.
Abstract
In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre- and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.
Additional Information
Copyright © 1992 . Received 17 June 1992. Revised 25 August 1992. Available online 14 April 2004. We thank Gary Balford, Scott Fraser, Mike Ito, Akiko Kumagai, Dale Laird, Liching Lo, Shelley Mueller, Bruce Patton, jeff Rawlings, and Show-Ling Shing for technical help and advice; Amy Greenwood for help with Figure 6; Karen Ross and leslie Schenker for help with Figure 7; Tammy Bower, Chris Akinson. and David Teplow of the Caltech Applied Microsequencing Facility for peptide sequencing; and II Soo Moon, jeff Rawlings, Paul Sternberg, and Kai Zinn for valuable comments on the manuscript. This work was supported by grants from the National Institutes of Health and the National Science Foundation and by the Pfeiffer and Drown Foundations. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisemenr' in accordance with 18 USC Section 1734 solely to indicate this fact.Additional details
- Eprint ID
- 30317
- DOI
- 10.1016/0896-6273(92)90245-9
- Resolver ID
- CaltechAUTHORS:20120424-151657008
- NIH
- NSF
- Pfeiffer Research Foundation
- Joseph Drown Foundation
- Created
-
2012-04-25Created from EPrint's datestamp field
- Updated
-
2021-11-09Created from EPrint's last_modified field