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Published March 9, 2012 | Published
Book Section - Chapter Open

Differential intensity contrast swept source optical coherence tomography for human retinal vasculature visualization

Abstract

We demonstrate an intensity-based motion sensitive method, called differential logarithmic intensity variance (DLOGIV), for 3D microvasculature imaging and foveal avascular zone (FAZ) visualization in the in vivo human retina using swept source optical coherence tomog. (SS-OCT) at 1060 nm. A motion sensitive SS-OCT system was developed operating at 50,000 A-lines/s with 5.9 μm axial resoln., and used to collect 3D images over 4 mm^2 in a normal subject eye. Multiple B-scans were acquired at each individual slice through the retina and the variance of differences of logarithmic intensities as well as the differential phase variances (DPV) was calcd. to identify regions of motion (microvasculature). En face DLOGIV image were capable of capturing the microvasculature through depth with an equal performance compared to the DPV.

Additional Information

© 2012 SPIE. Online Mar 09, 2012. This work was supported in part by research from the California Institute for Regenerative Medicine (CIRM). The authors thank Carl Zeiss Meditec for providing the patient interface part of their Stratus OCT system.

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