MicroRNAs in inflammation and immune responses
- Creators
- Contreras, J.
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Rao, D. S.
Abstract
MicroRNAs (miRNAs) are important regulators of gene expression in the immune system. In a few short years, their mechanism of action has been described in various cell lineages within the immune system, targets have been defined and their unique contributions to immune cell function have been examined. Certain miRNAs serve in important negative feedback loops in the immune system, whereas others serve to amplify the response of the immune system by repressing inhibitors of the response. Here, we review some of the better understood mechanisms as well as some emerging concepts of miRNA function. Future work will likely involve defining the function of specific miRNAs in specific immune cell lineages and to utilize them in the design of therapeutic strategies for diseases involving the immune system.
Additional Information
© 2012 Macmillan Publishers Limited. Received 4 September 2011; Revised 26 October 2011; Accepted 4 November 2011. Advance online publication 20 December 2011. Although this review is meant to be comprehensive, we acknowledge that we may not have included all papers in this large and growing field because of space limitations. We thank David Baltimore and Ryan O'Connell for helpful discussions over the years. DSR is a Kimmel Scholar of the Sidney Kimmel Foundation for Cancer Research and has received a career development award from the NIH (5K08-CA133251). JC is a recipient of the Eugene V. Cota-Robles Fellowship from UCLA.Additional details
- Eprint ID
- 29925
- Resolver ID
- CaltechAUTHORS:20120402-081524005
- 5K08CA133251
- NIH Career Development Award
- UCLA Eugene V. Cota-Robles Fellowship
- Created
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2012-04-02Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field