Flow-enhanced transient response in whispering gallery mode biosensors
- Creators
- Gamba, Jason M.
-
Flagan, Richard C.
Abstract
Whispering gallery mode (WGM) optical resonator sensors are an extremely sensitive label-free technology for detecting the binding of biomolecules in solution. To better understand the fast transient response observed with these devices, we model mass transfer to spherical and toroidal WGM sensors of identical outer radius. Finite element simulations predict a 3-10 fold higher binding frequency for toroidal sensors. These results agree to within an order of magnitude with experimental data from the literature and suggest a design strategy to improve the transient response of a sensor by making the device small only in the dimension that governs boundary layer development.
Additional Information
© 2011 American Institute of Physics. Received 1 September 2011; accepted 11 November 2011; published online 21 December 2011. This work was supported by funding from the Jacobs Institute for Molecular Engineering for Medicine at the California Institute of Technology.Attached Files
Published - Gamba2011p17097Appl_Phys_Lett.pdf
Erratum - Gamba2012p18028Appl_Phys_Lett.pdf
Files
| Name | Size | Download all |
|---|---|---|
|
md5:5c7bc6999acd7aec4a6019bb701b878d
|
522.8 kB | Preview Download |
|
md5:e3b1eb3e0d74709b57989404f390e787
|
361.6 kB | Preview Download |
Additional details
- Eprint ID
- 29257
- Resolver ID
- CaltechAUTHORS:20120213-110848252
- Jacobs Institute for Molecular Engineering for Medicine
- Created
-
2012-02-14Created from EPrint's datestamp field
- Updated
-
2021-11-09Created from EPrint's last_modified field