The X-chromosome archetype for non-coding RNA regulation of the epigenome
- Creators
- Kim, Daniel H.
- Lee, Jeannie T.
- Other:
- Kevin, Morris
Abstract
X-chromosome inactivation provides a model for discovering the still emerging functions of non-coding RNAs, which exhibit diverse roles in regulating the epigenome. Combining recent insights into X-chromosome non-coding RNAs with the advent of next-generation sequencing technologies promises many new discoveries in interrogating the functions of non-coding RNAs at the genomic level. Global RNA-protein interaction information can now be queried by utilizing RNA immunoprecipitation followed by high-throughput sequencing (RIP-Seq), which has recently uncovered the diversity of the non-coding Polycomb transcriptome. In this chapter, we discuss non-coding RNAs of the X-inactivation center that have provided unique insights into RNA molecules as molecular switches, guides and tethers to the epigenome, and key participants in diverse regulatory pathways, including RNA interference and Polycomb silencing.
Additional Information
© 2012 Caister Academic Press. We thank all laboratory members for valuable discussions. D.H.K. is supported by a Damon Runyon Cancer Research Foundation Fellowship (DRG-#2027-09) and the Beckman Fellows Program at Caltech. J.T.L is an Investigator of the Howard Hughes Medical Institute.Additional details
- Eprint ID
- 28604
- Resolver ID
- CaltechAUTHORS:20120103-091849897
- 2027-09
- Damon Runyon Cancer Research Foundation Fellowship
- Caltech Beckman Fellows Program
- Created
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2012-01-06Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field