Quantitative Model for Efficient Temporal Targeting of Tumor Cells and Neovasculature
Abstract
The combination of cytotoxic therapies and antiangiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors. However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome. Using a mathematical modeling approach that is grounded on available experimental data, we investigate the spatial and temporal targeting of tumor cells and neovasculature with a nanoscale delivery system. Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue. The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.
Additional Information
© 2011 M. Kohandel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received 13 July 2010; Accepted 9 January 2011. Academic Editor: Nestor V. Torres. The authors are grateful to G. Powathil for comments on the manuscript. M. Kohandel and S. Sivaloganathan acknowledge financial support by the Natural Sciences and Engineering Research Council of Canada (NSERC) and Canadian Institutes of Health Research (CIHR). C. A. Haselwandter was supported at MIT by an Erwin Schrödinger fellowship of the Austrian Science Fund, and M. Kardar is supported by the NSF Grant no. DMR-08-03315. S. Sengupta is supported by a DoD Era of Hope Scholar award.Attached Files
Published - CMMM2011-790721.pdf
Files
Name | Size | Download all |
---|---|---|
md5:87160ed1bc686983adea64f35418683b
|
3.1 MB | Preview Download |
Additional details
- PMCID
- PMC3065043
- Eprint ID
- 27641
- Resolver ID
- CaltechAUTHORS:20111107-084221045
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR)
- FWF Der Wissenschaftsfonds
- DMR-0803315
- NSF
- Department of Defense (DoD)
- Created
-
2011-11-07Created from EPrint's datestamp field
- Updated
-
2023-06-02Created from EPrint's last_modified field