A DNA superstructure-based replicator without product inhibition
- Creators
- Zhang, David Y.
- Yurke, Bernard
Abstract
A monomer structure based on a hairpin loop is described that can be linked via short oligonucleotide sequences (linkers) to form polymers. Independence of linked monomers allow for exponential complexity of the polymer structure. A method is described wherein the polymer structure can be replicated semi-conservatively with fidelity, given a source of monomer structures and linkers. Furthermore, the separation of the product from the parent allows for exponential amplification. These steps are achieved by secondary structure constraints and toehold-mediated strand displacement, and occur in the absence of enzymes. The parallel polymerization allows for replication to be achieved in O(log N) time, as opposed to O(N) from a processive process.
Additional Information
© 2006 Springer. The authors would like to thank Robert Barish and Si-ping Han for proofreading assistance.Additional details
- Eprint ID
- 27348
- DOI
- 10.1007/s11047-005-4465-x
- Resolver ID
- CaltechAUTHORS:20111021-090226357
- Created
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2011-10-24Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field