Published June 8, 2011
| Supplemental Material + Accepted Version
Journal Article
Open
Protonolysis of a Ruthenium–Carbene Bond and Applications in Olefin Metathesis
Abstract
The synthesis of a ruthenium complex containing an N-heterocylic carbene (NHC) and a mesoionic carbene (MIC) is described wherein addition of a Brønsted acid results in protonolysis of the Ru–MIC bond to generate an extremely active metathesis catalyst. Mechanistic studies implicated a rate-determining protonation step in the generation of the metathesis-active species. The activity of the NHC/MIC catalyst was found to exceed those of current commercial ruthenium catalysts.
Additional Information
© 2011 American Chemical Society. Received: April 4, 2011. Published: May 16, 2011. Lawrence Henling and Dr. Michael Day are acknowledged for X-ray crystallographic analysis. Prof. Dennis Dougherty and Dr. Jay Labinger are thanked for helpful discussions. We are grateful to Dr. Alexey Fedorov for assisting with mass spectrometry studies and instrumentation. Financial support by NDSEG (fellowship to B.K.K.), FQNRT (fellowship to J.B.), NIH (R01GM68825, 5R01GM031332), and NSF (CHE-1048404) is acknowledged. The instrumentation facilities where this work was carried out were supported by NSF CHE-063094 and NIH RR027690.Attached Files
Accepted Version - nihms297164.pdf
Supplemental Material - ja203070r_si_001.pdf
Supplemental Material - ja203070r_si_002.cif
Files
nihms297164.pdf
Additional details
- PMCID
- PMC3121189
- Eprint ID
- 24233
- Resolver ID
- CaltechAUTHORS:20110628-084528883
- National Defense Science and Engineering Graduate (NDSEG) Fellowship
- Fonds Québécois de la Recherche sur la Nature et les Technologies (FQRNT)
- R01GM68825
- NIH
- 5R01GM031332
- NIH
- RR027690
- NIH
- CHE-1048404
- NSF
- CHE-063094
- NSF
- Created
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2011-06-28Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field