Analysis of autocatalytic networks in biology

Abstract

Autocatalytic networks, in particular the glycolytic pathway, constitute an important part of the cell metabolism. Changes in the concentration of metabolites and catalyzing enzymes during the lifetime of the cell can lead to perturbations from its nominal operating condition. We investigate the effects of such perturbations on stability properties, e.g., the extent of regions of attraction, of a particular family of autocatalytic network models. Numerical experiments demonstrate that systems that are robust with respect to perturbations in the parameter space have an easily "verifiable" (in terms of proof complexity) region of attraction properties. Motivated by the computational complexity of optimization-based formulations, we take a compositional approach and exploit a natural decomposition of the system, induced by the underlying biological structure, into a feedback interconnection of two input–output subsystems: a small subsystem with complicating nonlinearities and a large subsystem with simple dynamics. This decomposition simplifies the analysis of large pathways by assembling region of attraction certificates based on the input–output properties of the subsystems. It enables numerical as well as analytical construction of block-diagonal Lyapunov functions for a large family of autocatalytic pathways.

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