Published December 2010
| Published
Journal Article
Open
Recent advances in the total synthesis of agelastatins
- Creators
- Dong, Guangbin
Abstract
Agelastatins represent an important family of marine alkaloids in terms of both exceptional biological activity and intriguing chemical structure. In this article, the isolation and biological activity of agelastatins are reviewed, and proposed biosynthetic pathways are summarized. The main focus is given to comparative evaluation of recent total syntheses, mainly of agelastatin A. To date, this has been accomplished by 11 research groups. Their synthetic routes are analyzed and summarized, with a view to furnishing the reader with insight into different strategic design approaches to assembly of a densely functionalized and compact structure.
Additional Information
© 2010 IUPAC. Publication date (Web): 4 October 2010. I thank IUPAC for providing the opportunity to present this work; I also thank my Ph.D. mentor Prof. Barry M. Trost for his invaluable advice, guidance, and encouragement over the years. I thank Prof. Du Bois for helpful discussion and Prof. Movassaghi for sharing advanced information on their work. I thank the Stanford Graduate Fellowship and the Camille and Henry Dreyfus Environmental Chemistry Fellowship for funding. A collection of invited, peer-reviewed articles by the winners of the 2010 IUPAC Prize for Young Chemists.Attached Files
Published - Dong2010p12783Pure_Appl_Chem.pdf
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Dong2010p12783Pure_Appl_Chem.pdf
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Additional details
- Eprint ID
- 22703
- Resolver ID
- CaltechAUTHORS:20110308-081251047
- Stanford Graduate Fellowship
- Camille and Henry Dreyfus Environmental Chemistry Fellowship
- Created
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2011-03-08Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field