An electrochemical intraocular drug delivery device
Abstract
A microelectromechanical systems (MEMS) drug delivery device is investigated for the treatment of incurable ocular diseases. Unlike conventional ocular drug delivery devices, this MEMS device is capable of being refilled, features electronic control of the drug regimen, and enables targeted intraocular drug delivery. The refillable design permits long-term drug therapy and avoids repetitive surgeries. Electronic control of dosing is achieved by using electrolysis-actuated pumping to deliver pharmaceuticals directly to the intraocular space. A flexible Parylene transscleral cannula allows targeted delivery to tissues in both the anterior and posterior segments of the eye. This electrochemically driven drug delivery device was demonstrated to provide flow rates suitable for ocular drug therapy (pL/min to μL/min). Both continuous and bolus drug delivery modes were performed to achieve accurate delivery of a target volume of 250 nL. An encapsulation packaging technique was developed for acute surgical studies and preliminary ex vivo drug delivery experiments in porcine eyes were performed.
Additional Information
© 2007 Elsevier B.V. Received 31 March 2007; revised 22 June 2007; accepted 26 June 2007. Available online 4 July 2007. This work was funded in part by Engineering Research Centers Program of the NSF under Award Number EEC-0310723 and Bausch & Lomb.We would like to thank Mr. Trevor Roper, Dr. Tuan Hoang, and members of the Biomedical Microsystems Lab at the University of Southern California.Additional details
- Eprint ID
- 18950
- DOI
- 10.1016/j.sna.2007.06.034
- Resolver ID
- CaltechAUTHORS:20100708-110900771
- EEC-0310723
- NSF
- Bausch and Lomb
- Created
-
2010-07-09Created from EPrint's datestamp field
- Updated
-
2021-11-08Created from EPrint's last_modified field