Signal Processing during Developmental Multicellular Patterning
Abstract
Developing design strategies for tissue engineering and regenerative medicine is limited by our nascent understanding of how cell populations self-organize into multicellular structures on synthetic scaffolds. Mechanistic insights can be gleaned from the quantitative analysis of biomolecular signals that drive multicellular patterning during the natural processes of embryonic and adult development. This review describes three critical layers of signal processing that govern multicellular patterning: spatiotemporal presentation of extracellular cues, intracellular signaling networks that mediate crosstalk among extracellular cues, and finally, intranuclear signal integration at the level of transcriptional regulation. At every level in this hierarchy, the quantitative attributes of signals have a profound impact on patterning. We discuss how experiments and mathematical models are being used to uncover these quantitative features and their impact on multicellular phenotype.
Additional Information
© 2008 American Chemical Society and American Institute of Chemical Engineers. Received April 20, 2007. Accepted July 20, 2007. Published on Web 09/26/2007. The authors thank P. Sternberg and the members of the Asthagiri group for helpful discussions and for critical review of the manuscript. This work was supported by the Institute for Collaborative Biotechnologies Grant DAAD 19-03-D-0004 from the U.S. Army Research Office. C.A.G. was partially supported by the Center for Biological Circuit Design.Additional details
- Eprint ID
- 18925
- DOI
- 10.1021/bp070127t
- Resolver ID
- CaltechAUTHORS:20100707-112740611
- DAAD 19-03-D-0004
- Army Research Office
- Center for Biological Circuit Design
- Created
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2010-07-09Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field