Published March 17, 2010
| Supplemental Material
Journal Article
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Line Active Hybrid Lipids Determine Domain Size in Phase Separation of Saturated and Unsaturated Lipids
- Creators
- Brewster, Robert
- Safran, Samuel A.
Abstract
A simple model of the line activity of a hybrid lipid (e.g., POPC) with one fully saturated chain and one partially unsaturated chain demonstrates that these lipids preferentially pack at curved interfaces between phase-separated saturated and unsaturated domains. We predict that the domain sizes typically range from tens to hundreds of nm, depending on molecular interactions and parameters such as molecular volume and area per headgroup in the bulk fluid phase. The role of cholesterol is taken into account by an effective change in the headgroup areas and the domain sizes are predicted to increase with cholesterol concentration.
Additional Information
© 2010 Biophysical Society. Published by Elsevier Inc. Received 24 August 2009; accepted 18 November 2009. Editor: Lukas K. Tamm. Available online 16 March 2010. The authors thank Phil Pincus and Tetsuya Yamamoto for helpful discussions. We acknowledge support from the U.S.-Israel Binational Science Foundation, the U.S.-Israel Educational Foundation, and an Israeli Science Foundation Converging Technologies grant.Attached Files
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Additional details
- Eprint ID
- 17980
- Resolver ID
- CaltechAUTHORS:20100414-111003044
- U.S.-Israel Binational Science Foundation
- U.S.-Israel Educational Foundation
- Israeli Science Foundation
- Created
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2010-04-28Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field