Published February 19, 2010
| Supplemental Material
Journal Article
Open
Rapid Assembly of the Salvileucalin B Norcaradiene Core
- Creators
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Levin, Sergiy
- Nani, Roger R.
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Reisman, Sarah E.
Abstract
Preparation of the polycyclic core of the cytotoxic natural product salvileucalin B is described. The key feature of this synthetic strategy is a copper-catalyzed intramolecular arene cyclopropanation to provide the central norcaradiene. These studies lay the foundation for continued investigations toward an enantioselective total synthesis of 1.
Additional Information
© 2010 American Chemical Society. Received December 10, 2009. Publication Date (Web): January 20, 2010. We thank Dr. Scott Virgil and Dr. Jennifer Roizen of the California Institute of Technology for insightful discussions, as well as Prof. Brian Stoltz and the Caltech Center for Catalysis and Chemical Synthesis for access to analytical equipment. Financial support from the California Institute of Technology is gratefully acknowledged.Attached Files
Supplemental Material - ol902848k_si_001.pdf
Supplemental Material - ol902848k_si_002.pdf
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ol902848k_si_001.pdf
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Additional details
- Eprint ID
- 17649
- Resolver ID
- CaltechAUTHORS:20100303-133732724
- Caltech
- Created
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2010-03-12Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field