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Published July 31, 2009 | Supplemental Material + Published
Journal Article Open

Trajectory Approach to Two-State Kinetics of Single Particles on Sculpted Energy Landscapes

Abstract

We study the trajectories of a single colloidal particle as it hops between two energy wells which are sculpted using optical traps. Whereas the dynamical behaviors of such systems are often treated by master-equation methods that focus on particles as actors, we analyze them instead using a trajectory-based variational method called maximum caliber (MaxCal). We show that the MaxCal strategy accurately predicts the full dynamics that we observe in the experiments: From the observed averages, it predicts second and third moments and covariances, with no free parameters. The covariances are the dynamical equivalents of Maxwell-like equilibrium reciprocal relations and Onsager-like dynamical relations.

Additional Information

©2009 The American Physical Society. Received 3 March 2008; published 31 July 2009. We are grateful to Dave Drabold, Jane Kondev, Keir Neuman, and Dan Gillespie for helpful comments. K. D. appreciates the support of NIH Grant No. GM 34993 and a UCSF Sandler Blue Sky grant. D.W. acknowledges the support of a NIH UCLA-Caltech MD-PhD grant. This work was also supported by the NIH Director's Pioneer grant to R. P.

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Published - Wu2009p5578Phys_Rev_Lett.pdf

Supplemental Material - Supplemental_Information.pdf

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