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Published June 2009 | Published
Journal Article Open

Enantioselective γ-lactam synthesis via palladium-catalyzed intramolecular asymmetric allylic alkylation

Abstract

A Pd(0)-catalyzed intramolecular allylic alkylation in the presence of (R)-3,5-t-Bu-MeOBIPHEP takes place in up to 92:8 er in agreement with DFT calculations and provides easy access to enantioenriched disubstituted γ-lactams.

Additional Information

© 2009 Georg Thieme Verlag. Received: 13 February 2009; publication Date: 04 May 2009 (eFirst); 03 June 2009 (Print). CNRS and UPMC are acknowledged for financial support. The sponsorship of COST Action D40 'Innovative Catalysis: New Processes and Selectivities' is kindly acknowledged. PF thanks the Carlsberg and Lundbeck foundations for financial support. We thank Solvias for a gift of ligands, Prof. P. S. Pregosin for a sample of ligand L5, Prof. J.-P. Genêt for a sample of ligand L3, and Prof. P.-O. Norrby for fruitful discussions.

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Additional details

Created:
August 21, 2023
Modified:
October 18, 2023